Of reported reactions, vulvar swelling, attractiveness to male dogs, gastrointestinal signs, and localized or generalized hormonal-pattern alopecia were the most common observations.1,3. Press question mark to learn the rest of the keyboard shortcuts. Hmm, good input - thank you! Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Convenient - Given with food, a single dose per day simplifies treatment, Innovative - Patented release technology provides controlled release that ensures steady absorption, Easy to Administer - Liver-flavored tablets improve compliance. The vet will determine the dogs usual dose. Mandigers RJ, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. It can present as a congenital or acquired condition. July 25, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/882. Incurin is another FDA-approved Accessed October 2020. Urinary Incontinence in the Male and Female Dog or Does Sex Matter? Whilst not a cause of the condition, obesity may worsen the degree of incontinence and weight loss may improve the situation. By Mariah on Nov Proin, PPA for Urinary Incontinence in Spayed Dogs The alpha-adrenergic agonist, phenylpropanolamine, also known as PPA (Proin, Propalin), is a commonly prescribed treatment option for urethral incontinence. Phenylpropanolamine has been found to be efficacious at controlling incontinence secondary to USMI in several studies. 8. As in the bitch, the condition can occur as either a congenital or acquired condition. WebIncurin Tablets vs. Proin ER Comparison | PetMeds. In extra sensitive dogs, Proin may trigger an allergic reaction with symptoms like hives, facial swelling (lips, tongue), and breathing difficulties. If you buy something from a link on our site, we may earn a commision. I guess I meant when . with Rainey, she started urinating (and defecating) whenever we'd leave -- even if it was just for 40 minutes. Collins S, Caron MG, Lefkowitz RJ. is the only veterinary Food and Drug Administration (FDA)-approved phenylpropanolamine hydrochloride medication marketed in the United States to treat urinary incontinence due to hypotonicity of the urethral sphincter. Compare Incurin Tablets vs. Proin ER with a detailed product breakdown. 1987;8(5):497-505. The dose of Incurin is not dependent upon body weight. Kinn AC, Lindskog M. Estrogens and phenylpropanolamine in combination for stress urinary incontinence in postmenopausal women. Your link has been automatically embedded. We now have a prescription for DES. 5. Safely used worldwide for more than 16 years. In general terms, spayed animals are nearly eight times as likely to develop this form of urinary incontinence than entire bitches Spaying before the first season may increase the risk although this could not be proved conclusively in a recent study, probably because of the low number of animals examined. DES is no longer available commercially. Claritin for Dogs: Dosage, Benefits, Side Effects, and More! 3. The proportion of dogs achieving treatment success was statistically significantly greater (p = 0.0038) in the group treated with INCURIN Tablets (66%) than This only started near the end (and the seizures), before that she never did that in the house. 11. Atalan, G., Holt, P.E. My dog was on both proin and incurin for a while, then we weaned her to incurin only. Common side effects of Proin in dogs include diarrhea, vomiting, loss of appetite, weight loss, irritability, restlessness, agitation, vocalization, difficulty urinating, increased thirst (polydipsia), increased water intake, and lethargy. Our expert panel consists of licensed veterinarians and the knowledgeable staff of PetMed Express, Inc. d/b/a 1-800-PetMeds. Incurin is indicated for the treatment of urinary incontinence 2001;149(25):764-767. Based on the relatively low frequency and mildness of the adverse events and their level of association with estriol, no safety concerns associated with longer-term use of the product were observed.1,2, Estriol has been safely used worldwide in dogs for more than 16 years. Took her in for a lot of tests and the vet came back with older fixed female dogs have this problem some times and prescribed her proin. Schedule, update or cancel anytime, Reliable Flexible Since, the safe use of Proin in breeding dogs, pregnant and lactating females is not evaluated, it is best not to use the medication in these situations and avoid potential side effects. World Small Animal Veterinary Association World Congress Proceedings, 2004, Peter E. 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Most things i have heard about it are pretty positive so far. Then COVID hit, and her vet stopped seeing us in person. We'd make sure she did her business before we'd leave but no matter what, she'd pee and poop while we were gone. The only way to get DES now is through compounding pharmacies. Colposuspension is intended to move the intrapelvic bladder neck of bitches with urethral sphincter mechanism incompetence to an intra-abdominal position so that increases in intra-abdominal pressure can act simultaneously on the bladder and urethra. Phenylpropanolamine has an excellent bioavailability for both controlled-release and immediate-release formulations (93.7% and 98%, respectively) in dogs. 16. FREE Standard ShippingWhen You Spend $49+, EXTRA 40% OFFUse code NEW40 in cart (up to $40 discount), 2% Back on all PurchasesWith PetMeds Shop & Earn Rewards. Plumbs Veterinary Drug Handbook: Pocket. See our advertising disclosure. 2022 Veterinarian.org, LLC. 12. However, it must be noted that Proin is not a cure, it is a supplement, and it strengthens the bladder sphincter muscle only when used continuously. She gradually started leaking more over the last year. The Honest Kitchen Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, CBD for Dog Anxiety: Top 11 Products According to a Veterinarian, The Best Probiotics For Dogs in 2022 According to a Veterinarian, The Best Cat Food for Indoor Cats: Our Top 7 Picks, CBD for Cat Anxiety: Our Top 5 Picks + Reviews, The Farmers Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, Ollie Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, Open Farm Cat Food Reviewed: Pros, Cons, and Ingredient Analysis, By Katelyn Son | Updated November 28, 2022. 125, 478-480. The additional benefit is that Incurin is FDA approved and commercially available while DES has to be compounded. Ollie (whippet), Gracie (whippet x), & Terra (whippet) + Just Saying + Just Alice Although urethral pressure profilometry can be used to demonstrate incompetence of the urethral sphincter mechanism, this technique is not readily available in general practice and is predisposed to a number of artefacts which can make interpretation difficult. 22. Urol Int. Incurin contains the active substance estriol. That will teach you to keep your mouth shut." A similar variation in response is also seen with the use of alpha-adrenergic drugs Oestrogens sensitise the urethral smooth muscle to alpha-adrenergic stimulation and so a combination of oestrogen and alpha-adrenergic therapy may be useful and reduce the dose of each individual drug, lessening the chances of side effects. Biopharm Drug Dispos. (2002) Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. Care is taken to avoid compression of the urethra during the technique. One study showed that sympathomimetic drugs (pseudoephedrine) were more effective at controlling urinary incontinence than DES (82.4% versus 64.5%). It's possible that the Proin (which used to be an non-prescription appetite suppressant for humans) might be causing this. In one study, phenylpropanolamine was found to be effective at controlling unconscious urination in 85.7% of dogs treated with 1 mg/kg PO q8h.11 Studies funded by a manufacturer (Pegasus Laboratories Inc.) showed a significant reduction in urinary incontinence at 2 mg/kg PO q12h compared with placebo, with 91.3% of owners reporting satisfactory urinary continence by day 30 and 98.1% at day 180. My poo x got spayed last week at a low cost spay/neuter How to make family member's dog feel secure. Your previous content has been restored. Mandigers RJ, Nell T. Treatment of bitches with acquired urinary incontinence with oestriol. Freedom of Information Summary. Schedule, update or cancel anytime, Reliable Its so frustrating that the fact that she had zero leaks for the month she was on both. He said it is a more natural medication that is basically estrogen, and that once she is stabilized on it we can drop down her dose a bit and give it less frequently (every other day). Am. Your comment will be removed, and you may be banned. 18. That def makes me feel better! Vet. So Incurin vs DES? U.S. Food and Drug Administration. Expand section Collapse section A urodynamic and clinical evaluation. 2. On both medications - not a single drop. Incurin is another FDA-approved estrogen-based medication for the control of urinary incontinence in dogs. Forsee KM, Davis GJ, Mouat EE, et al. Never run out of what your pet needs the most when you sign up for AutoShip. Side effects of phenylpropanolamine may include restlessness, irritability, panting, excitability and increased blood pressure. The information presented is for educational purposes only and is intended to be a supplement to, and not a substitute for, the expertise and professional judgment of your veterinarian. I have had my 2.5 year old lab on Proin for a few weeks and it is helping, but her initial reaction to the meds made me a bit nervous, especially after looking up all the Cancel or update at anytime. U.S. Food and Drug Administration Center for Veterinary Medicine. Likewise, no legal liability or responsibility is assumed for the accuracy or completeness of any information, or usefulness of products discussed. Common Proin alternatives include Estrogen or Estrogen derivatives (like Diethylstilbestrol and Estriol). Press J to jump to the feed. Part 1: significance, clinical aspects and etiopathogenesis [in German]. It is not a substitute for a veterinary exam, and it does not replace the need for services provided by your veterinarian. Use code NEW40 in cart (up to $40 discount), Hoof Abscess Symptoms, Treatment, And Prevention, Proven effective in reducing or eliminating urinary incontinence, One simple starting dose for all female dogs, regardless of weight or age, Can be titrated to the lowest effective dose, Is a supplement for urinary incontinence in dogs, Ensures sustained phenylpropanolamine levels in the blood stream, May help reduce the conditions often associated with high levels of phenylpropanolamine such as: decreased appetite, changes in heart rate, increased blood pressure, hyperexcitability. & Barr, F.J. (1998) Ultrasonographic assessment of bladder neck mobility in continent bitches and bitches with urinary incontinence attributable to urethral sphincter mechanism incompetence. August 4, 2011. animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/881. A treatment for female canine urinary incontinence that contains estriol, a naturally occurring, short-acting estrogen found in female dogs with the convenience of once-a-day dosing. Safety studies performed by the manufacturer showed that dosing at up to 5 times the recommended dose for 6 months resulted in hypertension; however, the mean arterial pressure was not significantly different than that in the ideal dosing group and no evidence of target organ damage was noted at necropsy.4 Despite this, the heart rates of dogs in the 3 and 5 dosing groups were found to be significantly lower than control.4 Independently conducted studies showed a similar increase in hypertension with a compensatory decrease in heart rate.8 One case report has also associated the long-term use of phenylpropanolamine with the development of ventricular hypertrophy.13 Pets on phenylpropanolamine therapy should have their blood pressure closely monitored. Use of decongestants during pregnancy and the risk of birth defects. INCURIN and PROIN are also the only marketed estriol and phenylpropanolamine products that are manufactured to meet FDAs strict standards for quality, purity, and potency. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. J Steroid Biochem. The safety and effectiveness of Incurin Tablets have not been evaluated in dogs less than 1 year of age, intact female dogs, male dogs, dogs used for breeding, or lactating dogs. An increased risk of hypertension has been documented in patients receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), reserpine, or tricyclic antidepressants. Be removed, and More tricyclic antidepressants it are pretty positive so far to avoid compression of keyboard. Assumed for the accuracy or completeness of any information, or tricyclic antidepressants forsee KM, Davis,. 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